NFL 2025-2026 Week 2 Regular Season Predictions

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By: Evan Troxel

These are my predictions to win and lose for the 2025-26 National Football League season for Regular Season Week 2 from Thursday, September 11th, 2025, through Monday, September 15th, 2025!

NFL 2025-26 Regular Season Week 2 Predictions (Predicted on Tuesday, August 26th, 2025, at 7:19 p.m. Eastern Time)

Thursday, September 11th, 2025 (Prime Video, 8:15 p.m. Eastern Time)

Washington Commanders at Green Bay Packers

Predictions to win: Washington Commanders

Predictions to lose: Green Bay Packers

Results:

Sunday, September 14th, 2025 (1:00 p.m. Eastern Time games)

Jacksonville Jaguars at Cincinnati Bengals (CBS)

New York Giants at Dallas Cowboys (FOX)

Chicago Bears at Detroit Lions (FOX)

Los Angeles Rams at Tennessee Titans (CBS)

New England Patriots at Miami Dolphins (CBS)

San Francisco 49ers at New Orleans Saints (FOX)

Buffalo Bills at New York Jets (CBS)

Seattle Seahawks at Pittsburgh Steelers (FOX)

Cleveland Browns at Baltimore Ravens (CBS)

Predictions to win: Cincinnati Bengals, Dallas Cowboys, Detroit Lions, Los Angeles Rams, Miami Dolphins, San Francisco 49ers, Buffalo Bills, Seattle Seahawks, Baltimore Ravens

Predictions to lose: Jacksonville Jaguars, New York Giants, Chicago Bears, Tennessee Titans, New England Patriots, New Orleans Saints, New York Jets, Pittsburgh Steelers, Cleveland Browns

Results:

Sunday, September 14th, 2025 (Late afternoon games)

Denver Broncos at Indianapolis Colts (4:05 p.m. Eastern Time, CBS)

Carolina Panthers at Arizona Cardinals (4:05 p.m. Eastern Time, CBS)

Philadelphia Eagles at Kansas City Chiefs (4:25 p.m. Eastern Time, FOX)

Predictions to win: Denver Broncos, Arizona Cardinals, Kansas City Chiefs

Predictions to lose: Indianapolis Colts, Carolina Panthers, Philadelphia Eagles

Results:

Sunday Night Football on Sunday, September 14th, 2025 (NBC, 8:20 p.m. Eastern Time)

Atlanta Falcons at Minnesota Vikings

Predictions to win: Minnesota Vikings

Predictions to lose: Atlanta Falcons

Results:

Monday Night Football on Monday, September 15th, 2025

Tampa Bay Buccaneers at Houston Texans (7:00 p.m. Eastern Time, ABC & ESPN)

Los Angeles Chargers at Las Vegas Raiders (10:00 p.m. Eastern Time, ESPN)

Predictions to win: Tampa Bay Buccaneers, Los Angeles Chargers

Predictions to lose: Houston Texans, Las Vegas Raiders

Results:

Those are all of my predictions for right now! Be sure to come back to this page for my re-predictions of my NFL original predictions for Regular Season Week 2 (and also to see how many wins and losses I actually get with my original predictions and my re-predictions for Regular Season Week 2) and be sure to come back to this website for my predictions to win and lose for next week (and for every single week after that for the entire 2025-26 National Football League season or until as long as I want to keep making predictions)!

Be sure to follow me on my various social media which you can find on this page for right now. Also, be sure to follow me on Twitter/X @Evan_Troxel. Also, be sure to definitely follow me on Gab @Evan_Troxel as well in case I ever get censored and banned from X and Facebook!

I reserve the right to change my predictions before game time. I also can change my predictions AFTER game time ONLY if I decide BEFORE game time that I want to change my predictions and I just do not have access to the Internet before game time.

LEGAL NOTICE: I DO NOT endorse and I do not encourage people to gamble or bet your own money and other people's money at all! These predictions are not meant to be taken as extremely serious advice for betting and gambling purposes anytime at all in the near future!