NFL 2025-2026 Week 5 Regular Season Predictions

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(EDITOR'S NOTE: A lot of information posted here in this story is from statmuse.com, so please go use Statmuse for yourself to find any sports statistics and scores about all of your favorite athletes and teams in every major professional sport and strongly consider giving them your money to use their service for more detailed information if you already really like what you see when you use their services for free!)

By: Evan Troxel

These are my predictions to win and lose for the 2025-26 National Football League season for Regular Season Week 5 from Thursday, October 2nd, 2025, through Monday, October 6th, 2025!

NFL 2025-26 Regular Season Week 5 Predictions (Predicted on Tuesday, August 26th, 2025, at 8:42 p.m. Eastern Time)

Teams on a bye week this week: Atlanta Falcons, Chicago Bears, Green Bay Packers and Pittsburgh Steelers

Thursday, October 2nd, 2025 (Prime Video, 8:15 p.m. Eastern Time)

San Francisco 49ers at Los Angeles Rams

*Note: I messed up the notes with the early editions of this post/story for the 49ers-Rams game and wrote the stats for Monday games instead of Thursday and I wrote the stats for September games instead of October games. I believe I have corrected all of my mistakes and I totally apologize for messing up!

Stats updated/corrected on Wednesday, October 1st, 2025, after the regular season Week 4 games in the 2025-26 season

49ers 4-5 (-1 more wins, 9 games played, L1) on October 2nd all-time won-lost record

49ers 2-2 (+0 more wins, 4 games played, W1) all-time won-lost record on October 2nd AWAY

49ers 15-10-1 (+5 more wins, 26 games played, L1) all-time won-lost record REGULAR SEASON on Thursdays

49ers 11-4-1 (+7 more wins, 16 games played, W3) all-time won-lost record REGULAR SEASON on Thursdays AWAY

49ers 3-3 (+0 more wins, 6 games played, W2) all-time won-lost record REGULAR SEASON on Thursdays in October

49ers 2-1 (+1 more wins, 3 games played, W2) all-time won-lost record REGULAR SEASON on Thursdays in October AWAY

49ers 161-145-5 (+16 more wins, 311 games played, W1) all-time won-lost record REGULAR SEASON in October

49ers 81-75-2 (+6 more wins, 158 games played, W1) all-time won-lost record REGULAR SEASON in October AWAY

49ers 359-285-4 (+74 more wins, 648 games played, W3) against the NFC all-time in the regular season

49ers 167-157-1 (+10 more wins, 325 games played, W2) against the NFC AWAY all-time in the regular season

49ers 196-145-4 (+51 more wins, 345 games played, W2) against the NFC West all-time in the regular season

49ers 97-74-1 (+23 more wins, 172 games played, W1) against the NFC West AWAY all-time in the regular season

The 49ers have a winning percentage at or above .500 for ELEVEN of the above twelve data points. The 49ers are currently on a winning streak for TEN (it was previously EIGHT before I made corrections) of the 12 data points listed above. The combined winning and losing streaks of these twelve data points equals W16 (it was previously W13 before I made corrections).

Stats updated/corrected on Wednesday, October 1st, 2025, after the regular season Week 4 games in the 2025-26 season

Rams 6-5 (+1 more wins, 11 games played, W1) on October 2nd all-time won-lost record

Rams 4-3 (+1 more wins, 7 games played, L3) on October 2nd at HOME all-time won-lost record

Rams 15-11 (+4 more wins, 26 games played, W4) on Thursdays REGULAR SEASON all-time

Rams 8-5 (+3 more wins, 13 games played, W3) on Thursdays REGULAR SEASON HOME all-time

Rams 4-2 (+2 more wins, 6 games played, W2) all-time won-lost record REGULAR SEASON on Thursdays in October

Rams 3-0 (+3 more wins, 3 games played, W3) all-time won-lost record REGULAR SEASON on Thursdays in October at HOME

Rams 174-178-7 (-4 more wins, 359 games played, W2) all-time won-lost record REGULAR SEASON in October

Rams 95-69-5 (+26 more wins, 169 games played, W2) all-time won-lost record REGULAR SEASON in October HOME

Rams 323-320-5 (+3 more wins, 648 games played, L2) all-time won-lost record REGULAR SEASON against NFC

Rams 177-146-2 (+31 more wins, 325 games played, L1) all-time won-lost record REGULAR SEASON against NFC HOME

Rams 174-165-3 (+9 more wins, 342 games played, L1) all-time won-lost record REGULAR SEASON against NFC West

Rams 89-80-2 (+9 more wins, 171 games played, L1) all-time won-lost record REGULAR SEASON against NFC West HOME

The Rams have a winning percentage at or above .500 for ELEVEN of the above twelve data points. The Rams are currently on a winning streak for SEVEN (it was previously FIVE before I made corrections) of the 12 data points listed above. The combined winning and losing streaks of these twelve data points equals W9 (it was previously W2 before I made corrections).

49ers 77-70-3 (+7 more wins, 150 games played, L3) all-time won-lost record REGULAR SEASON against Rams

49ers 40-34-1 (+6 more wins, 75 games played, L1) all-time won-lost record AWAY REGULAR SEASON against Rams

The 49ers are 1-1 (+0 more wins, 2 game played, L1) against Rams on October 2nd all-time. The 49ers lost in 1977, 34-14, at the Rams on October 2nd. The Rams lost at the 49ers on 13-9 in 1960 on October 2nd.

The 49ers are 0-1 (-1 more wins, 1 game played, L1) against Rams AWAY on October 2nd all-time.

The 49ers are 2-2 (+0 more wins, 4 games played, L2) against the Rams on Thursdays all-time REGULAR SEASON. The Rams won at the 49ers on September 21st in 2017 41-39 and on December 12th, 2024, 12-6.

The 49ers are 2-0 (+2 more wins, 2 games played, W2) against the Rams on Thursdays AWAY all-time REGULAR SEASON. The 49ers won at the Rams 30-24 on December 2nd, 1982, and also at the Rams on September 26th, 2013, 35-11.

49ers 0-0 (+0 more wins, 0 games played) all-time won-lost record against Rams on Thursdays in October.

49ers 0-0 (+0 more wins, 0 games played) all-time won-lost record against Rams AWAY on Thursdays in October

49ers 29-20-1 (+9 more wins, 50 games played, W4) against Rams all-time won-lost record in October.

49ers 14-9-1 (+5 more wins, 24 games played, W3) against Rams all-time won-lost record in October AWAY.

The 49ers are 5-2 (+3 more wins, 7 games played, W1) all-time against the Rams in REGULAR SEASON Week 5, according to Statmuse.com if I am not mistaken. The 49ers last win was at home a 37-13 win on October 6th, 2002, 37-13. The Rams last win was at home at the then St. Louis Rams 42-20 on October 10th, 1999.

The 49ers are 2-2 (+0 more wins, 4 games played, L2) against the Rams AWAY in Regular Season Week 5 all-time. The 49ers last win AWAY against the 49ers in Week 5 was in 1976 on October 11th, 16-0.

The 49ers have a winning and losing streak against the Rams of W0 (it was previously L8 after I made corrections) based on all of the criteria after the 12 points criteria.

Thoughts: (Posted on Tuesday, September 30th, 2025, at 5:08 p.m. Eastern Time) For right now, I think this is a no brainer, at least for me. I think the Los Angeles Rams will win this game just because they are the home team! In the Monday Night Football games on September 29th, 2025, both teams who had the worse winning and losing streaks both won on Monday Night, so that's what I am thinking here as well going with the Rams at W2 over the 49ers at W13! The one concern is the L8 for the 49ers against the Rams in the sentence above these "Thoughts" is extremely concerning! By all accounts, Brock Purdy will start again on Thursday and that is not a good thing if you are any opponent of the 49ers this season. This is the Rams only NFC opponent this month (the Rams also had one NFC opponent in September 2025) and their only divisional opponent at home until November 16th! The Rams are finished with AFC opponents on October 19th, 2025, until Super Bowl 60 or until the 2026-27 season starts! The 49ers literally have to go on the road again next week at Tampa Bay while the Rams don't host another home game until November 2nd against New Orleans. The Rams have won two straight times after they have lost all season and they can do that again with a win on Thursday. The 49ers won five straight after they lost their first preseason game of the year and they can win five straight again by starting a new five-game winning streak by winning against the Rams on Thursday night.

(Posted on Wednesday, October 1st, 2025, at 8:26 p.m. Eastern Time): It looks like Brock Purdy won't be playing against the Rams on Thursday Night unless something changes between now and I guess early tomorrow morning. I think I am going to take the Rams to win this game! Based on everything that I have seen and read, this will be a very close game, but then again, last week was really close at the end on Thursday night, so this game honestly probably won't be that close at the very least, but I still think it will be at least somewhat close like within a field goal or touchdown at the very end of the game!

Predictions to win: Los Angeles Rams

Predictions to lose: San Francisco 49ers

Results: Loss (0-1 for Week 5)

Sunday, October 5th, 2025 (9:30 a.m. Eastern Time, NFL Network & NFL+, Tottenham Hotspur Stadium, London, England)

Minnesota Vikings at Cleveland Browns

Stats updated/corrected on Wednesday, October 1st, 2025, after the regular season Week 4 games in the 2025-26 season

Vikings 6-2 (+4 more wins, 8 games played, W4) on October 5th all-time won-lost record

Vikings 3-1 (+2 more wins, 4 games played, W3) all-time won-lost record on October 5th AWAY

Vikings 468-374-11 (+94 more wins, 853 games played, L1) all-time won-lost record REGULAR SEASON on Sundays

Vikings 191-217-7 (-26 more wins, 415 games played, L1) all-time won-lost record REGULAR SEASON on Sundays AWAY

Vikings 122-99-1 (+23 more wins, 222 games played, L1) all-time won-lost record REGULAR SEASON on Sundays in October

Vikings 56-55 (+1 more wins, 111 games played, W6) all-time won-lost record REGULAR SEASON on Sundays in October AWAY

Vikings 141-113-1 (+28 more wins, 255 games played, L2) all-time won-lost record REGULAR SEASON in October

Vikings 63-65 (-2 more wins, 128 games played, L1) all-time won-lost record REGULAR SEASON in October AWAY

Vikings 110-102 (+8 more wins, 212 games played, L1) against the AFC all-time in the regular season

Vikings 39-66 (-27 more wins, 105 games played, L1) against the AFC AWAY all-time in the regular season

Vikings 10-13 (-3 more wins, 23 games played, L1) against the AFC North all-time in the regular season

Vikings 2-10 (-8 more wins, 12 games played, L4) against the AFC North AWAY all-time in the regular season

The Vikings have a winning percentage at or above .500 for SEVEN of the above twelve data points. The Vikings are currently on a winning streak for THREE of the 12 data points listed above. The combined winning and losing streaks of these twelve data points equals W0.

Stats updated/corrected on Wednesday, October 1st, 2025, after the regular season Week 4 games in the 2025-26 season

Browns 7-3 (+4 more wins, 10 games played, W3) on October 5th all-time won-lost record

Browns 2-3 (-1 more wins, 5 games played, L3) on October 5th at HOME all-time won-lost record

Browns 463-502-11 (-39 more wins, 976 games played, L1) on Sundays REGULAR SEASON all-time

Browns 256-222-6 (+34 more wins, 484 games played, W1) on Sundays REGULAR SEASON HOME all-time

Browns 138-131-2 (+7 more wins, 271 games played, W1) all-time won-lost record REGULAR SEASON on Sundays in October

Browns 75-72-2 (+3 more wins, 149 games played, W1) all-time won-lost record REGULAR SEASON on Sundays in October at HOME

Browns 158-137-2 (+21 more wins, 297 games played, W1) all-time won-lost record REGULAR SEASON in October

Browns 89-77-2 (+12 more wins, 168 games played, W1) all-time won-lost record REGULAR SEASON in October HOME

Browns 85-115 (-30 more wins, 200 games played, L1) all-time won-lost record REGULAR SEASON against NFC

Browns 50-50 (+0 more wins, 100 games played, W1) all-time won-lost record REGULAR SEASON against NFC HOME

Browns 8-15 (-7 more wins, 23 games played, L1) all-time won-lost record REGULAR SEASON against NFC North

Browns 5-7 (-2 more wins, 126 games played, W4) all-time won-lost record REGULAR SEASON against NFC North HOME

The Browns have a winning percentage at or above .500 for SEVEN of the above twelve data points. The Browns are currently on a winning streak for EIGHT of the 12 data points listed above. The combined winning and losing streaks of these twelve data points equals W7.

Vikings 11-5 (+6 more wins, 16 games played, L1) all-time won-lost record REGULAR SEASON against Browns

Viking 5-2 (+3 more wins, 7 games played, W2) all-time won-lost record AWAY REGULAR SEASON against Browns

The Vikings have never played against the Browns on October 5th all-time.

The Vikings are 10-5 (+5 more wins, 15 games played, L1) against the Browns on Sundays all-time REGULAR SEASON.

The Vikings are 5-2 (+3 more wins, 7 games played, W2) against the Browns on Sundays AWAY all-time REGULAR SEASON.

Vikings 2-2 (+0 more wins, 4 games played, L1) all-time won-lost record against Browns on Sundays in October.

Vikings 2-0 (+2 more wins, 2 games played, W2) all-time won-lost record against Browns AWAY on Sundays in October

Vikings 2-2 (+0 more wins, 4 games played, L1) against Browns all-time won-lost record in October.

Vikings 2-0 (+2 more wins, 2 games played, W2) against Browns all-time won-lost record in October AWAY.

The Vikings have never played against the Browns all-time in Week 5, according to Statmuse.com.

The Vikings have a winning and losing streak against the Browns of W4 based on all of the criteria after the 12 points criteria for each team.

Thoughts: (Posted on Thursday, October 2nd, 2025, at 1:49 p.m. Eastern Time) Right now, I like the Minnesota Vikings to win this game because I genuinely believe they are the better team and also I think they are more due for a win than the Cleveland Browns! Also, they lost last week in an international game, so that should give them some type of advantage to get a win on Sunday, October 5th!

Predictions to win: Cleveland Browns

Predictions to lose: Minnesota Vikings

CHANGE IN PREDICTION(S)

Predicted at or shortly after the game started on Gab.com/Evan_Troxel on Sunday, October 5th, 2025!

Predictions to win: Minnesota Vikings

Predictions to lose: Cleveland Browns

Results: Win (1-1 in Week 5)

Sunday, October 5th, 2025 (1:00 p.m. Eastern Time games)

Las Vegas Raiders at Indianapolis Colts (FOX)

Stats updated/corrected on Wednesday, October 1st, 2025, after the regular season Week 4 games in the 2025-26 season

Raiders 2-5 (-3 more wins, 7 games played, L2) on October 5th all-time won-lost record

Raiders 2-3 (-1 more wins, 5 games played, L1) all-time won-lost record on October 5th AWAY

Raiders 433-406-6 (+27 more wins, 845 games played, L2) all-time won-lost record REGULAR SEASON on Sundays

Raiders 185-215-4 (-30 more wins, 404 games played, L1) all-time won-lost record REGULAR SEASON on Sundays AWAY

Raiders 124-98-2 (+26 more wins, 224 games played, L5) all-time won-lost record REGULAR SEASON on Sundays in October

Raiders 53-52 (+1 more wins, 105 games played, L5) all-time won-lost record REGULAR SEASON on Sundays in October AWAY

Raiders 139-114-6 (+25 more wins, 259 games played, L6) all-time won-lost record REGULAR SEASON in October

Raiders 62-67-4 (-5 more wins, 133 games played, L7) all-time won-lost record REGULAR SEASON in October AWAY

Raiders 325-318-5 (+7 more wins, 648 games played, L1) against the AFC all-time in the regular season

Raiders 144-177-3 (-33 more wins, 324 games played, W1) against the AFC AWAY all-time in the regular season

Raiders 18-26 (-8 more wins, 44 games played, W1) against the AFC South all-time in the regular season

Raiders 9-13 (-4 more wins, 22 games played, L3) against the AFC South AWAY all-time in the regular season

The Raiders have a winning percentage at or above .500 for FIVE of the above twelve data points. The Raiders are currently on a winning streak for TWO of the 12 data points listed above. The combined winning and losing streaks of these twelve data points equals L31.

Stats updated/corrected on Wednesday, October 1st, 2025, after the regular season Week 4 games in the 2025-26 season

Colts 5-3 (+2 more wins, 8 games played, W2) on October 5th all-time won-lost record

Colts 2-1 (+1 more wins, 3 games played, W1) on October 5th at HOME all-time won-lost record

Colts 505-460-7 (+45 more wins, 972 games played, L1) on Sundays REGULAR SEASON all-time

Colts 278-212-5 (+66 more wins, 495 games played, W4) on Sundays REGULAR SEASON HOME all-time

Colts 145-119-2 (+26 more wins, 266 games played, L1) all-time won-lost record REGULAR SEASON on Sundays in October

Colts 71-55-1 (+22 more wins, 133 games played, W1) all-time won-lost record REGULAR SEASON on Sundays in October at HOME

Colts 161-133-2 (+28 more wins, 296 games played, L1) all-time won-lost record REGULAR SEASON in October

Colts 85-60-1 (+25 more wins, 146 games played, W1) all-time won-lost record REGULAR SEASON in October HOME

Colts 338-324-2 (+14 more wins, 664 games played, W5) all-time won-lost record REGULAR SEASON against NFC

Colts 182-151-1 (+31 more wins, 334 games played, W4) all-time won-lost record REGULAR SEASON against NFC HOME

Colts 53-55 (-2 more wins, 108 games played, W1) all-time won-lost record REGULAR SEASON against NFC North

Colts 24-30 (-6 more wins, 54 games played, W2) all-time won-lost record REGULAR SEASON against NFC North HOME

The Colts have a winning percentage at or above .500 for TEN of the above twelve data points. The Colts are currently on a winning streak for NINE of the 12 data points listed above. The combined winning and losing streaks of these twelve data points equals W18.

Colts 10-10 (+0 more wins, 20 games played, W2) all-time won-lost record REGULAR SEASON against Raiders

Colts 3-6 (-3 more wins, 9 games played, W1) all-time won-lost record HOME REGULAR SEASON against Raiders

The Colts have never played against the Raiders on October 5th all-time.

The Colts are 10-9 (+1 more wins, 19 games played, W2) against the Raiders on Sundays all-time REGULAR SEASON.

The Colts are 3-6 (-3 more wins, 9 games played, W1) against the Raiders on Sundays HOME all-time REGULAR SEASON.

Colts 2-3 (-1 more wins, 5 games played, W2) all-time won-lost record against Raiders on Sundays in October.

Colts 1-2 (-1 more wins, 3 games played, W1) all-time won-lost record against Raiders HOME on Sundays in October

Colts 2-3 (-1 more wins, 5 games played, W2) against Raiders all-time won-lost record in October.

Colts 1-2 (-1 more wins, 3 games played, W1) against Raiders all-time won-lost record in October HOME.

The Colts are 1-1 (+0 more wins, 2 games played, W1) against the Raiders all-time in Week 5, according to Statmuse.com.

The Colts are 1-1 (+0 more wins, 2 games played, W1) against the Raiders AT HOME all-time in Week 5, according to Statmuse.com.

The Colts have a winning and losing streak against the Raiders of W14 based on all of the criteria after the 12 points criteria for each team.

Thoughts: (Posted on Wednesday, October 1st, 2025): I expect the Colts to more likely than not to win this game. This feels like it could be a gigantic upset and the Raiders could win if you want to take a chance on the Raiders and if you really really really like them as your favorite NFL team of course. I don't expect this game to be close at all and I expect the Colts to absolutely dominate and crush the Raiders. If the Raiders do win, the final score probably will be close though. The Raiders are in a giant hole right now and I don't really expect them to win this game at all! I'm not going to change my current prediction right now, but I will probably change it (but no 100 percent guarantees) before Sunday's game after I analyze all of the other matchups in regular season Week 5! The thing that bothers me the most is that the Colts looks so good (W18) compared to the Raiders (L31) as the Dolphins were almost just as bad as the Jets on Monday Night Football on September 29th, 2025!

(Posted on Thursday, October 2nd, 2025, at 1:53 p.m. Eastern Time): I am seriously thinking about picking the Raiders to win this game, but I probably won't have the inclination to actually do it before game time this week, maybe I will do it for the Raiders within the next four or five weeks!

New York Giants at New Orleans Saints (CBS)

Stats updated/corrected on Thursday, October 2nd, 2025, after the regular season Week 4 games in the 2025-26 season

Giants 7-7 (+0 more wins, 14 games played, W2) on October 5th all-time won-lost record

Giants 3-5 (-2 more wins, 8 games played, W1) all-time won-lost record on October 5th AWAY

Giants 642-573-27 (+69 more wins, 1,242 games played, W1) all-time won-lost record REGULAR SEASON on Sundays

Giants 272-293-11 (-21 more wins, 576 games played, L7) all-time won-lost record REGULAR SEASON on Sundays AWAY

Giants 206-158-8 (+48 more wins, 372 games played, L2) all-time won-lost record REGULAR SEASON on Sundays in October

Giants 88-84-4 (+4 more wins, 176 games played, W1) all-time won-lost record REGULAR SEASON on Sundays in October AWAY

Giants 223-185-10 (+38 more wins, 418 games played, L3) all-time won-lost record REGULAR SEASON in October

Giants 99-103-6 (-4 more wins, 208 games played, L1) all-time won-lost record REGULAR SEASON in October AWAY

Giants 301-357-4 (-56 more wins, 662 games played, L10) against the AFC all-time in the regular season

Giants 137-194-2 (-57 more wins, 333 games played, L6) against the AFC AWAY all-time in the regular season

Giants 20-27 (-7 more wins, 47 games played, L5) against the AFC North all-time in the regular season

Giants 9-14 (-5 more wins, 23 games played, L4) against the AFC North AWAY all-time in the regular season

The Giants have a winning percentage at or above .500 for FIVE of the above twelve data points. The Giants are currently on a winning streak for FOUR of the 12 data points listed above. The combined winning and losing streaks of these twelve data points equals L33.

Stats updated/corrected on Thursday, October 2nd, 2025, after the regular season Week 4 games in the 2025-26 season

Saints 2-5 (-3 more wins, 7 games played, W1) on October 5th all-time won-lost record

Saints 1-2 (-1 more wins, 3 games played, W1) on October 5th at HOME all-time won-lost record

Saints 377-439-5 (-62 more wins, 821 games played, L7) on Sundays REGULAR SEASON all-time

Saints 199-203-1 (-4 more wins, 403 games played, L5) on Sundays REGULAR SEASON HOME all-time

Saints 111-110-3 (+1 more wins, 224 games played, L2) all-time won-lost record REGULAR SEASON on Sundays in October

Saints 61-52 (+9 more wins, 113 games played, L2) all-time won-lost record REGULAR SEASON on Sundays in October at HOME

Saints 117-115-3 (+2 more wins, 235 games played, L4) all-time won-lost record REGULAR SEASON in October

Saints 65-55 (+10 more wins, 120 games played, L4) all-time won-lost record REGULAR SEASON in October HOME

Saints 308-341-2 (-33 more wins, 651 games played, L6) all-time won-lost record REGULAR SEASON against NFC

Saints 169-156 (+13 more wins, 325 games played, L4) all-time won-lost record REGULAR SEASON against NFC HOME

Saints 59-68 (-9 more wins, 127 games played, L1) all-time won-lost record REGULAR SEASON against NFC North

Saints 35-28 (+7 more wins, 63 games played, L2) all-time won-lost record REGULAR SEASON against NFC North HOME

The Saints have a winning percentage at or above .500 for SIX of the above twelve data points. The Saints are currently on a winning streak for TWO of the 12 data points listed above. The combined winning and losing streaks of these twelve data points equals L35.

Giants 17-16 (+1 more wins, 33 games played, L2) all-time won-lost record REGULAR SEASON against Saints

Giants 5-10 (-5 more wins, 15 games played, L1) all-time won-lost record AWAY REGULAR SEASON against Saints

The Giants have never played against the Saints on October 5th all-time.

The Giants are 15-14 (+1 more wins, 29 games played, L2) against the Saints on Sundays all-time REGULAR SEASON.

The Giants are 3-9 (-6 more wins, 12 games played, L1) against the Saints on Sundays AWAY all-time REGULAR SEASON.

Giants 6-4 (+2 more wins, 10 games played, W1) all-time won-lost record against Saints on Sundays in October.

Giants 2-4 (-2 more wins, 6 games played, W1) all-time won-lost record against Saints AWAY on Sundays in October

Giants 6-4 (+2 more wins, 10 games played, W1) against Saints all-time won-lost record in October.

Giants 2-4 (-2 more wins, 6 games played, W1) against Saints all-time won-lost record in October AWAY.

The Giants are 1-2 (-1 more wins, 3 games played, W1) against the Saints all-time in Week 5, according to Statmuse.com.

The Giants are 0-2 (-2 more wins, 2 games played, L2) against the Saints all-time AWAY in Week 5, according to Statmuse.com.

The Giants have a winning and losing streak against the Saints of L3 based on all of the criteria after the 12 points criteria for each team.

Thoughts: (Posted on Thursday, October 2nd, 2025): This is a really tough prediction. If I were you, I wouldn't even bet any money at all for any part of this game! This game is extremely dangerous! Jackson Dart, the former Ole Miss product for the Giants has a chip on his shoulder that the nearby Saints didn't draft him. This is probably the worst game you will see all week if not all year (in terms of teams who have a realistic shot to make the playoffs, but the execution will definitely be there on defense for both teams since everybody pretty much has somewhat a good idea about what to expect at this point of the season)! This game probably won't be boring though! I expect some points to be put up, like a 20-17 final at least (or something like that). The Saints really need a win. I really want to pick the Giants to win this game though because of Jackson Dart, but I just don't think I can do it! Like I said, the Saints really need a win soon and it appears they will win this week or in a few weeks for sure! This will be a last minute decision on what I decide to do with this game prediction and maybe I will just take the Giants to win this game!

(Posted on Thursday, October 2nd, 2025, at 1:55 p.m. Eastern Time): I might take the Giants to win this game because they appear to be the underdog. According to ESPN Bet, the Giants are NOT the underdog at -2.5 right now!

Dallas Cowboys at New York Jets (FOX)

Denver Broncos at Philadelphia Eagles (CBS)

Stats updated/corrected on Thursday, October 2nd, 2025, after the regular season Week 4 games in the 2025-26 season

Broncos 5-3 (+2 more wins, 8 games played, W2) on October 5th all-time won-lost record

Broncos 1-2 (-1 more wins, 3 games played, L1) all-time won-lost record on October 5th AWAY

Broncos 451-386-8 (+65 more wins, 845 games played, L2) all-time won-lost record REGULAR SEASON on Sundays

Broncos 177-229-2 (-52 more wins, 408 games played, L2) all-time won-lost record REGULAR SEASON on Sundays AWAY

Broncos 128-99 (+29 more wins, 227 games played, W1) all-time won-lost record REGULAR SEASON on Sundays in October

Broncos 54-54 (+0 more wins, 108 games played, W2) all-time won-lost record REGULAR SEASON on Sundays in October AWAY

Broncos 143-120-2 (+23 more wins, 265 games played, W2) all-time won-lost record REGULAR SEASON in October

Broncos 59-68-1 (-9 more wins, 128 games played, W1) all-time won-lost record REGULAR SEASON in October AWAY

Broncos 120-92-2 (+28 more wins, 214 games played, W4) against the AFC all-time in the regular season

Broncos 46-58-2 (-12 more wins, 106 games played, W2) against the AFC AWAY all-time in the regular season

Broncos 34-26-1 (+8 more wins, 61 games played, L2) against the AFC North all-time in the regular season

Broncos 12-16-1 (-4 more wins, 29 games played, W2) against the AFC North AWAY all-time in the regular season

The Broncos have a winning percentage at or above .500 for SEVEN of the above twelve data points. The Broncos are currently on a winning streak for EIGHT of the 12 data points listed above. The combined winning and losing streaks of these twelve data points equals W9.

Stats updated/corrected on Thursday, October 2nd, 2025, after the regular season Week 4 games in the 2025-26 season

Eagles 10-3 (+7 more wins, 13 games played, W1) on October 5th all-time won-lost record

Eagles 9-3 (+6 more wins, 12 games played, W1) on October 5th at HOME all-time won-lost record

Eagles 553-564-26 (-11 more wins, 1,143 games played, W5) on Sundays REGULAR SEASON all-time

Eagles 310-246-13 (+64 more wins, 569 games played, W8) on Sundays REGULAR SEASON HOME all-time

Eagles 157-169-4 (-12 more wins, 330 games played, W5) all-time won-lost record REGULAR SEASON on Sundays in October

Eagles 85-62-2 (+23 more wins, 149 games played, W6) all-time won-lost record REGULAR SEASON on Sundays in October at HOME

Eagles 182-185-5 (-3 more wins, 372 games played, W5) all-time won-lost record REGULAR SEASON in October

Eagles 104-70-3 (+34 more wins, 177 games played, W6) all-time won-lost record REGULAR SEASON in October HOME

Eagles 120-87-3 (+33 more wins, 210 games played, W9) all-time won-lost record REGULAR SEASON against NFC

Eagles 69-34-1 (+35 more wins, 104 games played, W8) all-time won-lost record REGULAR SEASON against NFC HOME

Eagles 31-27 (+4 more wins, 58 games played, W3) all-time won-lost record REGULAR SEASON against NFC North

Eagles 16-10 (+6 more wins, 26 games played, L2) all-time won-lost record REGULAR SEASON against NFC North HOME

The Eagles have a winning percentage at or above .500 for NIINE of the above twelve data points. The Eagles are currently on a winning streak for ELEVEN of the 12 data points listed above. The combined winning and losing streaks of these twelve data points equals W55.

Broncos 5-9 (-4 more wins, 14 games played, L2) all-time won-lost record REGULAR SEASON against Eagles

Broncos 1-6 (-5 more wins, 7 games played, L4) all-time won-lost record AWAY REGULAR SEASON against Eagles

The Broncos have never played against the Eagles on October 5th all-time.

The Broncos are 5-9 (-4 more wins, 14 games played, L2) against the Eagles on Sundays all-time REGULAR SEASON.

Broncos 1-6 (-5 more wins, 7 games played, L4) against the Eagles on Sundays AWAY all-time REGULAR SEASON.

Broncos 2-2 (+0 more wins, 4 games played, W2) all-time won-lost record against Eagles on Sundays in October.

Broncos 0-1 (-1 more wins, 1 games played, L1) all-time won-lost record against Eagles AWAY on Sundays in October

Broncos 2-2 (+0 more wins, 4 games played, W2) against Eagles all-time won-lost record in October.

Broncos 0-1 (-1 more wins, 1 games played, L1) against Eagles all-time won-lost record in October AWAY.

The Broncos are 1-0 (+1 more wins, 1 games played, W1) against the Eagles all-time in Week 5, according to Statmuse.com.

The Broncos have a winning and losing streak against the Eagles of L9 based on all of the criteria after the 12 points criteria for each team.

Thoughts: (Posted on Thursday, October 2nd, 2025, at 2:49 p.m. Eastern Time): This could be a massive upset if the Broncos win! But I really don't expect the Broncos to win this game! I almost really want to make Denver winning as my final prediction, but I really doubt I will do it (even though I currently do have Denver winning this game)! Denver destroyed the Chiefs last year in the last week of the regular season, then got absolutely hammered by the Buffalo Bills in the playoffs! The Broncos beating the Eagles is about as likely as the Raiders defeating the Colts this week...it is one percent and it just isn't happening most likely!

Miami Dolphins at Carolina Panthers (FOX)

Houston Texans at Baltimore Ravens (FOX)

Predictions to win: Las Vegas Raiders, New Orleans Saints, Dallas Cowboys, Denver Broncos, Miami Dolphins, Houston Texans,

Predictions to lose: Indianapolis Colts, New York Giants, New York Jets, Philadelphia Eagles, Carolina Panthers, Baltimore Ravens,

Results: Loss, Win, Win, Loss, Loss Win (2-1 for final predictions in the early afternoon slate of games on Sunday, 3-2 for final predictions in Week 5)

CHANGE IN PREDICTION(S)

Predicted at or shortly after the game started on Gab.com/Evan_Troxel on Sunday, October 5th, 2025!

Predictions to win: Indianapolis Colts, Philadelphia Eagles, Baltimore Ravens

Predictions to lose: Las Vegas Raiders, Denver Broncos, Houston Texans

Results: Win, Loss, Loss (4-4 for final predictions in Week 5 up to this point!)

Sunday, October 5th, 2025 (Late afternoon games)

Tennessee Titans at Arizona Cardinals (4:05 p.m. Eastern Time, CBS)

Tampa Bay Buccaneers at Seattle Seahawks (4:05 p.m. Eastern Time, CBS)

Detroit Lions at Cincinnati Bengals (4:25 p.m. Eastern Time, FOX)

Washington Commanders at Los Angeles Chargers (4:25 p.m. Eastern Time, FOX)

Predictions to win: Arizona Cardinals, Tampa Bay Buccaneers, Detroit Lions, Los Angeles Chargers

Predictions to lose: Tennessee Titans, Seattle Seahawks, Cincinnati Bengals, Washington Commanders

Results: Loss, Win, Win, Loss (1-1 for final predictions in the late afternoon slate of games on Sunday, 5-5 for final predictions in Week 5)

CHANGE IN PREDICTION(S)

Predicted at or shortly after the game started on Gab.com/Evan_Troxel on Sunday, October 5th, 2025!

Predictions to win: Tennessee Titans, Seattle Seahawks

Predictions to lose: Arizona Cardinals, Tampa Bay Buccaneers

Results: Win, Loss (6-6 for final predictions in Week 5 up to this point!)

Sunday Night Football on Sunday, October 5th, 2025 (NBC, 8:20 p.m. Eastern Time)

New England Patriots at Buffalo Bills

Stats updated/corrected on Friday, October 3rd, 2025, after the regular season Week 4 games in the 2025-26 season

Patriots 6-4 (+2 more wins, 10 games played, L1) on October 5th all-time won-lost record

Patriots 3-3 (+0 more wins, 6 games played, L1) all-time won-lost record on October 5th AWAY

Patriots 468-380-6 (+88 more wins, 854 games played, W1) all-time won-lost record REGULAR SEASON on Sundays

Patriots 209-217-2 (-8 more wins, 428 games played, W1) all-time won-lost record REGULAR SEASON on Sundays AWAY

Patriots 128-103-3 (+25 more wins, 234 games played, W1) all-time won-lost record REGULAR SEASON on Sundays in October

Patriots 52-63-1 (-11 more wins, 116 games played, L4) all-time won-lost record REGULAR SEASON on Sundays in October AWAY

Patriots 149-119-5 (+30 more wins, 273 games played, W1) all-time won-lost record REGULAR SEASON in October

Patriots 61-71-1 (-10 more wins, 133 games played, L4) all-time won-lost record REGULAR SEASON in October AWAY

Patriots 374-283 (+91 more wins, 657 games played, L1) against the AFC all-time in the regular season

Patriots 159-169 (-10 more wins, 328 games played, W1) against the AFC AWAY all-time in the regular season

Patriots 223-168 (+55 more wins, 391 games played, W2) against the AFC East all-time in the regular season

Patriots 96-99 (-3 more wins, 195 games played, W1) against the AFC East AWAY all-time in the regular season

The Patriots have a winning percentage at or above .500 for SEVEN of the above twelve data points. The Patriots are currently on a winning streak for SEVEN of the 12 data points listed above. The combined winning and losing streaks of these twelve data points equals L3.

Stats updated/corrected on Friday, October 3rd, 2025, after the regular season Week 4 games in the 2025-26 season

Bills 6-4 (+2 more wins, 10 games played, W1) on October 5th all-time won-lost record

Bills 4-1 (+3 more wins, 5 games played, W3) on October 5th at HOME all-time won-lost record

Bills 428-442-5 (-14 more wins, 875 games played, W3) on Sundays REGULAR SEASON all-time

Bills 256-191-3 (+65 more wins, 450 games played, W13) on Sundays REGULAR SEASON HOME all-time

Bills 113-115-1 (-2 more wins, 229 games played, W2) all-time won-lost record REGULAR SEASON on Sundays in October

Bills 69-48-1 (+21 more wins, 118 games played, W2) all-time won-lost record REGULAR SEASON on Sundays in October at HOME

Bills 133-128-2 (+5 more wins, 263 games played, W3) all-time won-lost record REGULAR SEASON in October

Bills 82-55-1 (+27 more wins, 138 games played, W3) all-time won-lost record REGULAR SEASON in October HOME

Bills 314-341-1 (-27 more wins, 656 games played, W3) all-time won-lost record REGULAR SEASON against AFC

Bills 183-147 (+36 more wins, 330 games played, W11) all-time won-lost record REGULAR SEASON against AFC HOME

Bills 189-202-1 (-13 more wins, 392 games played, W2) all-time won-lost record REGULAR SEASON against AFC East

Bills 104-92 (+12 more wins, 196 games played, W11) all-time won-lost record REGULAR SEASON against AFC East HOME

The Bills have a winning percentage at or above .500 for EIGHT of the above twelve data points. The Bills are currently on a winning streak for TWELVE of the 12 data points listed above. The combined winning and losing streaks of these twelve data points equals W57.

Patriots 78-50-1 (+28 more wins, 129 games played, W1) all-time won-lost record REGULAR SEASON against Bills

Patriots 37-26-1 (+11 more wins, 64 games played, L3) all-time won-lost record AWAY REGULAR SEASON against Bills

The Patriots have never played against the Bills on October 5th all-time.

The Patriots are 68-43 (+25 more wins, 111 games played, W1) against the Bills on Sundays all-time REGULAR SEASON.

Patriots 33-23 (+10 more wins, 56 games played, L4) against the Bills on Sundays AWAY all-time REGULAR SEASON.

Patriots 15-7 (+8 more wins, 22 games played, W2) all-time won-lost record against Bills on Sundays in October.

Patriots 7-5 (+2 more wins, 12 games played, W4) all-time won-lost record against Bills AWAY on Sundays in October

Patriots 18-9 (+9 more wins, 27 games played, W3) against Bills all-time won-lost record in October.

Patriots 9-7 (+2 more wins, 16 games played, W5) against Bills all-time won-lost record in October AWAY.

The Patriots are 1-1 (+0 more wins, 2 games played, W1) against the Bills all-time in Week 5, according to Statmuse.com.

The Patriots are 0-1 (-1 more wins, 1 games played, L1) against the Bills all-time in Week 5 AWAY, according to Statmuse.com.

The Patriots have a winning and losing streak against the Bills of W9 based on all of the criteria after the 12 points criteria for each team.

Thoughts: (Posted on Friday, October 3rd, 2025, at 2:49 p.m. Eastern Time): I really like the Bills to win this game! Until W9 from two sentences ago is down to like W2 or W1 or worse (like L5), I would take the Bills to win this game! The Patriots still have to pay for all of Tom Brady's domination! The reason to not take the Bills, is that they have been much more dominant than their opponents especially when you have the Bills at W57 against the Patriots L3 (see the 12 points section). You might want to take the Patriots to win this game (or for any matchup in Week 5) when the Patriots are at like L11 or L20 and the Bills are at like W80 or W90! The point is, is that I totally expect the Bills to destroy the Patriots in this game on Sunday Night, and plus, you probably should just take the Bills to win every game they play at home this regular season (or at the very least this year, like the actual year of 2025) at least anyway!

Predictions to win: Buffalo Bills

Predictions to lose: New England Patriots

Results: Loss (6-7 for final predictions in Week 5 up to this point!)

Monday Night Football on Monday, October 6th, 2025

Kansas City Chiefs at Jacksonville Jaguars (8:15 p.m. Eastern Time, ABC & ESPN)

Stats updated/corrected on Friday, October 3rd, 2025, after the regular season Week 4 games in the 2025-26 season

Chiefs 3-3 (+0 more wins, 6 games played, L1) on October 6th all-time won-lost record

Chiefs 2-1 (+1 more wins, 3 games played, W2) all-time won-lost record on October 6th AWAY

Chiefs 35-21 (+14 more wins, 56 games played, W2) all-time won-lost record REGULAR SEASON on Mondays

Chiefs 15-12 (+3 more wins, 27 games played, W3) all-time won-lost record REGULAR SEASON on Mondays AWAY

Chiefs 16-4 (+12 more wins, 20 games played, W11) all-time won-lost record REGULAR SEASON on Mondays in October

Chiefs 5-1 (+4 more wins, 6 games played, W5) all-time won-lost record REGULAR SEASON on Mondays in October AWAY

Chiefs 141-119-3 (+22 more wins, 263 games played, W3) all-time won-lost record REGULAR SEASON in October

Chiefs 59-66-3 (-7 more wins, 128 games played, W2) all-time won-lost record REGULAR SEASON in October AWAY

Chiefs 346-313-5 (+33 more wins, 664 games played, W1) against the AFC all-time in the regular season

Chiefs 146-184-3 (-38 more wins, 333 games played, L2) against the AFC AWAY all-time in the regular season

Chiefs 23-21 (+2 more wins, 44 games played, W5) against the AFC South all-time in the regular season

Chiefs 12-10 (+2 more wins, 22 games played, W2) against the AFC South AWAY all-time in the regular season

The Chiefs have a winning percentage at or above .500 for TEN of the above twelve data points. The Chiefs are currently on a winning streak for TEN of the 12 data points listed above. The combined winning and losing streaks of these twelve data points equals W33.

Stats updated/corrected on Friday, October 3rd, 2025, after the regular season Week 4 games in the 2025-26 season

Jaguars 2-3 (-1 more wins, 5 games played, W1) on October 6th all-time won-lost record

Jaguars 2-0 (+2 more wins, 2 games played, W2) on October 6th at HOME all-time won-lost record

Jaguars 8-9 (-1 more wins, 17 games played, L3) on Mondays REGULAR SEASON all-time

Jaguars 7-5 (+2 more wins, 12 games played, L2) on Mondays REGULAR SEASON HOME all-time

Jaguars 3-3 (+0 more wins, 6 games played, W1) all-time won-lost record REGULAR SEASON on Mondays in October

Jaguars 2-2 (+0 more wins, 4 games played, W1) all-time won-lost record REGULAR SEASON on Mondays in October at HOME

Jaguars 46-74 (-28 more wins, 120 games played, L1) all-time won-lost record REGULAR SEASON in October

Jaguars 25-33 (-8 more wins, 58 games played, L1) all-time won-lost record REGULAR SEASON in October HOME

Jaguars 160-203 (-43 more wins, 363 games played, W1) all-time won-lost record REGULAR SEASON against AFC

Jaguars 94-88 (+6 more wins, 182 games played, W2) all-time won-lost record REGULAR SEASON against AFC HOME

Jaguars 33-23 (-10 more wins, 56 games played, L3) all-time won-lost record REGULAR SEASON against AFC West

Jaguars 14-15 (-1 more wins, 29 games played, L1) all-time won-lost record REGULAR SEASON against AFC West HOME

The Jaguars have a winning percentage at or above .500 for FIVE of the above twelve data points. The Jaguars are currently on a winning streak for SIX of the 12 data points listed above. The combined winning and losing streaks of these twelve data points equals L3.

Jaguars 6-9 (-3 more wins, 15 games played, L7) all-time won-lost record REGULAR SEASON against Chiefs

Jaguars 4-4 (+0 more wins, 8 games played, L3) all-time won-lost record HOME REGULAR SEASON against Chiefs

The Jaguars have never played against the Chiefs on October 5th all-time, on Mondays all-time or on a Monday in October all-time!

Jaguars 2-2 (+0 more wins, 4 games played, L2) against Chiefs all-time won-lost record in October.

Jaguars 1-0 (+1 more wins, 1 games played, W1) against Chiefs all-time won-lost record in October HOME.

The Jaguars are 1-1 (+0 more wins, 2 games played, L1) against the Chiefs all-time in Week 5, according to Statmuse.com.

The Jaguars are 0-0 (+0 more wins, 0 games played) against the Chiefs AT HOME all-time in Week 5, according to Statmuse.com.

The Jaguars have a winning and losing streak against the Chiefs of L12 based on all of the criteria after the 12 points criteria for each team.

Thoughts: (Posted on Friday, October 3rd, 2025, at 2:58 p.m. Eastern Time): I like the Chiefs to win this game very much! If you want to go the route of saying, the Jaguars are due for a win very soon or right now, then take the Jaguars to win this game! But just know that the Chiefs are probably going to win this game! Also, the 49ers (road team) won in a road game at the Los Angeles Rams on Thursday Night and the Chiefs can do that again to close out Week 5!

More notes/thoughts based on what has already happened in regular season Week 5: (Posted at 6:45 p.m. Eastern Time) Teams in games who had +0 or better according to the winning and losing streak methodology against this week's opponent, just above the "Thoughts" section, so for this game it is L12 for the Jaguars against the Chiefs specifically, are 3-0 including on Thursday Night Football, the morning international game for U.S. residents and Sunday Night Football! So, yes, the Patriots were technically W9 against the Bills on Sunday Night! I am not really worried about this game because people are going to go absolutely crazy if the Jaguars ACTUALLY win after the Patriots shocking (but not really surprising) win last night on Sunday Night! I don't think there is going to be a shocking win two nights in a row! This game is very very dangerous though and the Jaguars can win on Trevor Lawrence's 26th birthday today/tonight! I really really really want to pick the Jaguars to ACTUALLY win this game, but I just don't think I can do it! I think I will tell you in next week's notes why the Jaguars will lose tonight, because I don't want to tip anybody off about what I really think!

Predictions to win: Kansas City Chiefs

Predictions to lose: Jacksonville Jaguars

Results:

Those are all of my predictions for right now! Be sure to come back to this page for my re-predictions of my NFL original predictions for Regular Season Week 5 (and also to see how many wins and losses I actually get with my original predictions and my re-predictions for Regular Season Week 5) and be sure to come back to this website for my predictions to win and lose for next week (and for every single week after that for the entire 2025-26 National Football League season or until as long as I want to keep making predictions)!

Be sure to follow me on my various social media which you can find on this page for right now. Also, be sure to follow me on Twitter/X @Evan_Troxel. Also, be sure to definitely follow me on Gab @Evan_Troxel as well in case I ever get censored and banned from X and Facebook!

I reserve the right to change my predictions before game time. I also can change my predictions AFTER game time ONLY if I decide BEFORE game time that I want to change my predictions and I just do not have access to the Internet before game time.

LEGAL NOTICE: I DO NOT endorse and I do not encourage people to gamble or bet your own money and other people's money at all! These predictions are not meant to be taken as extremely serious advice for betting and gambling purposes anytime at all in the near future!