NFL 2025-2026 Week 5 Regular Season Predictions

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By: Evan Troxel

These are my predictions to win and lose for the 2025-26 National Football League season for Regular Season Week 5 from Thursday, October 2nd, 2025, through Monday, October 6th, 2025!

NFL 2025-26 Regular Season Week 5 Predictions (Predicted on Tuesday, August 26th, 2025, at 8:42 p.m. Eastern Time)

Teams on a bye week this week: Atlanta Falcons, Chicago Bears, Green Bay Packers and Pittsburgh Steelers

Thursday, October 2nd, 2025 (Prime Video, 8:15 p.m. Eastern Time)

San Francisco 49ers at Los Angeles Rams

Predictions to win: Los Angeles Rams

Predictions to lose: San Francisco 49ers

Results:

Sunday, October 5th, 2025 (9:30 a.m. Eastern Time, NFL Network & NFL+, Tottenham Hotspur Stadium, London, England)

Minnesota Vikings at Cleveland Browns

Predictions to win: Cleveland Browns

Predictions to lose: Minnesota Vikings

Results:

Sunday, October 5th, 2025 (1:00 p.m. Eastern Time games)

Las Vegas Raiders at Indianapolis Colts (FOX)

New York Giants at New Orleans Saints (CBS)

Dallas Cowboys at New York Jets (FOX)

Denver Broncos at Philadelphia Eagles (CBS)

Miami Dolphins at Carolina Panthers (FOX)

Houston Texans at Baltimore Ravens (FOX)

Predictions to win: Las Vegas Raiders, New Orleans Saints, Dallas Cowboys, Denver Broncos, Miami Dolphins, Houston Texans,

Predictions to lose: Indianapolis Colts, New York Giants, New York Jets, Philadelphia Eagles, Carolina Panthers, Baltimore Ravens,

Results:

Sunday, October 5th, 2025 (Late afternoon games)

Tennessee Titans at Arizona Cardinals (4:05 p.m. Eastern Time, CBS)

Tampa Bay Buccaneers at Seattle Seahawks (4:05 p.m. Eastern Time, CBS)

Detroit Lions at Cincinnati Bengals (4:25 p.m. Eastern Time, FOX)

Washington Commanders at Los Angeles Chargers (4:25 p.m. Eastern Time, FOX)

Predictions to win: Arizona Cardinals, Tampa Bay Buccaneers, Detroit Lions, Los Angeles Chargers

Predictions to lose: Tennessee Titans, Seattle Seahawks, Cincinnati Bengals, Washington Commanders

Results:

Sunday Night Football on Sunday, October 5th, 2025 (NBC, 8:20 p.m. Eastern Time)

New England Patriots at Buffalo Bills

Predictions to win: Buffalo Bills

Predictions to lose: New England Patriots

Results:

Monday Night Football on Monday, October 6th, 2025

Kansas City Chiefs at Jacksonville Jaguars (8:15 p.m. Eastern Time, ABC & ESPN)

Predictions to win: Kansas City Chiefs

Predictions to lose: Jacksonville Jaguars

Results:

Those are all of my predictions for right now! Be sure to come back to this page for my re-predictions of my NFL original predictions for Regular Season Week 5 (and also to see how many wins and losses I actually get with my original predictions and my re-predictions for Regular Season Week 5) and be sure to come back to this website for my predictions to win and lose for next week (and for every single week after that for the entire 2025-26 National Football League season or until as long as I want to keep making predictions)!

Be sure to follow me on my various social media which you can find on this page for right now. Also, be sure to follow me on Twitter/X @Evan_Troxel. Also, be sure to definitely follow me on Gab @Evan_Troxel as well in case I ever get censored and banned from X and Facebook!

I reserve the right to change my predictions before game time. I also can change my predictions AFTER game time ONLY if I decide BEFORE game time that I want to change my predictions and I just do not have access to the Internet before game time.

LEGAL NOTICE: I DO NOT endorse and I do not encourage people to gamble or bet your own money and other people's money at all! These predictions are not meant to be taken as extremely serious advice for betting and gambling purposes anytime at all in the near future!