NFL 2025-26 Week 1 Regular Season Predictions

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By: Evan Troxel

These are my predictions to win and lose for the 2025-26 National Football League season for Regular Season Week 1 from Thursday, September 4th, 2025, through Monday, September 8th, 2025!

NFL 2025-26 Regular Season Week 1 Predictions (Predicted on Wednesday, August 20th, 2025, at 9:12 p.m. Eastern Time)

Thursday, September 4th, 2025 (NBC & Peacock, 8:20 p.m. Eastern Time)

Dallas Cowboys at Philadelphia Eagles

Predictions to win: Philadelphia Eagles

Predictions to lose: Dallas Cowboys

Results:

Friday, September 5th, 2025 (YouTube, 8:00 p.m. Eastern Time)

Kansas City Chiefs at Los Angeles Chargers

Corinthians Arena, Sao Paulo, Brazil

Predictions to win: Los Angeles Chargers

Predictions to lose: Kansas City Chiefs

Results:

Sunday, September 7th, 2025 (1:00 p.m. Eastern Time games)

Tampa Bay Buccaneers at Atlanta Falcons (FOX)

Cincinnati Bengals at Cleveland Browns (FOX)

Miami Dolphins at Indianapolis Colts (CBS)

Las Vegas Raiders at New England Patriots (CBS)

Arizona Cardinals at New Orleans Saints (CBS)

Pittsburgh Steelers at New York Jets (CBS)

New York Giants at Washington Commanders (FOX)

Carolina Panthers at Jacksonville Jaguars (FOX)

Predictions to win: Tampa Bay Buccaneers, Cleveland Browns, Miami Dolphins, Las Vegas Raiders, New Orleans Saints, New York Jets, Washington Commanders, Jacksonville Jaguars

Predictions to lose: Atlanta Falcons, Cincinnati Bengals, Indianapolis Colts, New England Patriots, Arizona Cardinals, Pittsburgh Steelers, New York Giants, Carolina Panthers

Results:

Sunday, September 7th, 2025 (Late afternoon games)

Tennessee Titans at Denver Broncos (4:05 p.m. Eastern Time, FOX)

San Francisco 49ers at Seattle Seahawks (4:05 p.m. Eastern Time, FOX)

Detroit Lions at Green Bay Packers (4:25 p.m. Eastern Time, CBS)

Houston Texans at Los Angeles Rams (4:25 p.m. Eastern Time, CBS)

Predictions to win: Denver Broncos, Seattle Seahawks, Detroit Lions, Los Angeles Rams

Predictions to lose: Tennessee Titans, San Francisco 49ers, Green Bay Packers, Houston Texans

Results:

Sunday Night Football on Sunday, September 7th, 2025 (NBC, 8:20 p.m. Eastern Time)

Baltimore Ravens at Buffalo Bills

Predictions to win: Baltimore Ravens

Predictions to lose: Buffalo Bills

Results:

Monday Night Football on Monday, September 8th, 2025 (ABC & ESPN, 8:15 p.m. Eastern Time)

Minnesota Vikings at Chicago Bears

Predictions to win: Chicago Bears

Predictions to lose: Minnesota Vikings

Results:

Those are all of my predictions for right now! Be sure to come back to this page for my re-predictions of my NFL original predictions for Regular Season Week 1 (and also to see how many wins and losses I actually get with my original predictions and my re-predictions for Regular Season Week 1) and be sure to come back to this website for my predictions to win and lose for next week (and for every single week after that for the entire 2025-26 National Football League season or until as long as I want to keep making predictions)!

Be sure to follow me on my various social media which you can find on this page for right now. Also, be sure to follow me on Twitter/X @Evan_Troxel. Also, be sure to definitely follow me on Gab @Evan_Troxel as well in case I ever get censored and banned from X and Facebook!

I reserve the right to change my predictions before game time. I also can change my predictions AFTER game time ONLY if I decide BEFORE game time that I want to change my predictions and I just do not have access to the Internet before game time.

LEGAL NOTICE: I DO NOT endorse and I do not encourage people to gamble or bet your own money and other people's money at all! These predictions are not meant to be taken as extremely serious advice for betting and gambling purposes anytime at all in the near future!