NFL 2025-26 Week 3 Regular Season Predictions

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(EDITOR'S NOTE: A lot of information posted here in this story is from statmuse.com, so please go use Statmuse for yourself to find any sports statistics and scores about all of your favorite athletes and teams in every major professional sport and strongly consider giving them your money to use their service for more detailed information if you already really like what you see when you use their services for free!)

By: Evan Troxel

These are my predictions to win and lose for the 2025-26 National Football League season for Regular Season Week 3 from Thursday, September 18th, 2025, through Monday, September 22nd, 2025!

NFL 2025-26 Regular Season Week 3 Predictions (Predicted on Tuesday, August 26th, 2025, at 7:42 p.m. Eastern Time)

Thursday, September 18th, 2025 (Prime Video, 8:15 p.m. Eastern Time)

Miami Dolphins at Buffalo Bills

Predictions to win: Miami Dolphins

Predictions to lose: Buffalo Bills

Results: Loss (0-1)

The Bills are 1-1 (+0 more wins, 2 games played, L1) against the Dolphins on September 14th all-time. The Bills have always been the home team against the Dolphins on September 18th all-time.

The Bills are 2-1 (+1 more wins, 3 games played, W1) against the Dolphins on Thursdays all-time. The Bills are 1-0 (+1 more wins, 1 games played, W1) on Thursdays against the Dolphins at HOME all-time.

The Bills are 2-4 (-2 more wins, 6 games played, L1) against the Dolphins in regular season Week 3. The Bills are 1-1 (+0 more wins, 2 games played, L1) against the Dolphins at HOME in regular season Week 3 all-time! This information comes from statmuse.com which you can use for free or you can pay Statmuse if you wish to do so.

Stats posted/listed on Wednesday, September 17th, 2025, after the regular season Week 2 games in the 2025-26 season

Dolphins are 5-4 (+1 more wins, 9 games played, W1) on September 18th all-time

Dolphins 13-13 (+0 more wins, 26 games played, L3) on Thursdays all-time

Dolphins 7-10 (-3 more wins, 17 games played, L2) on Thursdays AWAY all-time

Dolphins 2-4 (-2 more wins, 6 games played, L2) on Thursdays in September all-time

Dolphins 1-3 (-2 more wins, 4 games played, L1) in September on Thursdays AWAY all-time

Dolphins 52-56-1 (-4 more wins, 109 games played, L2) in September AWAY all-time

Dolphins 364-287-2 (+77 more wins, 653 games played, L3) against the AFC all-time in the regular season

Dolphins 151-174-1 (-23 more wins, 326 games played, L2) against the AFC AWAY all-time in the regular season

Dolphins 220-173-1 (+47 more wins, 394 games played, L2) against the AFC East all-time in the regular season

Dolphins 91-106 (-15 more wins, 197 games played, L2) against the AFC East AWAY all-time in the regular season

The Dolphins have a winning percentage at or above .500 for FOUR of the above ten data points. The Dolphins are currently on a winning streak for ONE of the 10 data points listed above.

Stats posted/listed on Wednesday, September 17th, 2025, after the regular season Week 2 games in the 2025-26 season

Bills are 5-4 (+1 more wins, 9 games played, W1) on September 18th all-time

Bills 14-10-1 (+4 more wins, 25 games played, W7) on Sundays all-time

Bills 3-3 (+0 more wins, 6 games played, W1) on Thursdays HOME all-time

Bills 3-2 (+1 more wins, 5 games played, W2) on Thursdays in September all-time

Bills 1-2 (-1 more wins, 3 games played, L1) in September on Thursdays HOME all-time

Bills 76-60-1 (+16 more wins, 137 games played, W6) in September HOME all-time

Bills 313-341-1 (-28 more wins, 655 games played, W2) against the AFC all-time in the regular season

Bills 182-147 (+35 more wins, 329 games played, W9) against the AFC HOME all-time in the regular season

Bills 188-202-1 (-14 more wins, 391 games played, W1) against the AFC East all-time in the regular season

Bills 103-92 (+11 more wins, 195 games played, W10) against the AFC East HOME all-time in the regular season

The Bills have a winning percentage at or above .500 for SEVEN of the above ten data points. The Bills are currently on a winning streak for NINE of the 10 data points listed above.

Sunday, September 21st, 2025 (1:00 p.m. Eastern Time games)

Green Bay Packers at Cleveland Browns (FOX)

Indianapolis Colts at Tennessee Titans (CBS)

Second game on September 21st against each other all-time. The Titans won when they were the then Houston Oilers and the Colts were the then Baltimore Colts. The game was in Houston and the Oilers won 21-16 in 1980.

The Colts are 35-19 (+16 more wins, 54 games played, W4) against the Titans on Sundays all-time. The Colts are 15-8 (+7 more wins, 23 games played, W2) on Sundays against the Titans AWAY all-time.

The Colts are 1-3 (-2 more wins, 4 games played, L1) against the Titans in regular season Week 3 all-time. Also, all of those games were an away game for the Colts. This information comes from statmuse.com which you can use for free or you can pay Statmuse if you wish to do so.

Stats posted/listed on Friday afternoon, September 19th, 2025, after the regular season Week 2 games in the 2025-26 season

Colts are 4-6 (-2 more wins, 10 games played, L1) on September 21st all-time

Colts 504-459-7 (+45 more wins, 970 games played, W3) on Sundays all-time

Colts 226-247-2 (-21 more wins, 475 games played, L2) on Sundays AWAY all-time

Colts 96-106-1 (-10 more wins, 203 games played, W4) on Sundays in September all-time

Colts 44-50-1 (-6 more wins, 95 games played, L1) in September on Sundays AWAY all-time

Colts 46-54-1 (-8 more wins, 101 games played, L1) in September AWAY all-time

Colts 337-324-2 (+13 more wins, 663 games played, W4) against the AFC all-time in the regular season

Colts 155-173-1 (-18 more wins, 329 games played, L1) against the AFC AWAY all-time in the regular season

Colts 90-47-1 (+43 more wins, 138 games played, W2) against the AFC South all-time in the regular season

Colts 40-28-1 (+12 more wins, 69 games played, L1) against the AFC South AWAY all-time in the regular season

The Colts have a winning percentage at or above .500 for FOUR of the above ten data points. The Colts are currently on a winning streak for FOUR of the 10 data points listed above.

Titans are 5-4 (+1 more wins, 9 games played, L1) on September 21st all-time

Titans 420-463-5 (-43 more wins, 888 games played, L8) on Sundays all-time

Titans 241-200-2 (+41 more wins, 443 games played, L5) on Sundays at HOME all-time

Titans 89-109 (-20 more wins, 198 games played, L6) on Sundays in September all-time

Titans 47-47 (+0 more wins, 94 games played, L3) in September on Sundays at HOME all-time

Titans 53-50 (+3 more wins, 103 games played, L3) in September HOME all-time

Titans 303-344-1 (-41 more wins, 648 games played, L6) against the AFC all-time in the regular season

Titans 177-146 (+31 more wins, 323 games played, L3) against the AFC all-time HOME in the regular season

Titans 65-73 (-8 more wins, 138 games played, L4) against the AFC South all-time in the regular season

Titans 35-34 (+1 more wins, 69 games played, L3) against the AFC South at HOME all-time in the regular season

The Titans have a winning percentage at or above .500 for SIX of the above ten data points. The Titans are currently on a winning streak for ZERO of the 10 data points listed above.

Cincinnati Bengals at Minnesota Vikings (CBS)

Pittsburgh Steelers at New England Patriots (CBS)

Los Angeles Rams at Philadelphia Eagles (FOX)

The then Cleveland Rams won 21-3 at the Philadelphia Eagles on September 21st, 1937 (88 years ago) in the only game between the two teams on September 21st!

The Rams are 15-21-1 (-6 more wins, 37 games played, L2) against the Eagles on Sundays all-time. The Rams are 7-13 (-6 more wins, 20 games played, W1) on Sundays against the Eagles AWAY all-time.

The Rams are 47-34-1 (+13 more wins, 82 games played) in regular season Week 3 all-time (if I am not mistaken).

The Eagles are 47-36-2 (+11 more wins, 85 games played) in regular season Week 3 all-time (if I am not mistaken).

The Rams are 2-0-1 (+2 more wins, 3 games played, Tie 1) against the Eagles in regular season Week 3 (if I am not mistaken).

The Rams are 15-17 (-2 more wins, 32 games played, W1) all-time in regular season Week 3 SINCE the 1992-93 season (if I am not mistaken, I am pretty sure this is correct)!

This information comes from statmuse.com which you can use for free or you can pay Statmuse if you wish to do so.

IGNORE these notes about last week's Rams-Titans game (if you want to)!

Stats posted/listed on Monday afternoon, September 8th, 2025, after the regular season Week 1 games in the 2025-26 season

Rams are 6-6 (+0 more wins, 12 games played, W1) on September 21st all-time

Rams 556-532-20 (+24 more wins, 1,108 games played, W2) on Sundays all-time

Rams 251-305-11 (-54 more wins, 567 games played, W5) on Sundays AWAY all-time

Rams 114-93-3 (+21 more wins, 210 games played, W2) on Sundays in September all-time

Rams 49-58-2 (-9 more wins, 109 games played, W1) in September on Sundays AWAY all-time

Rams 58-65-2 (-7 more wins, 125 games played, W1) in September AWAY all-time

Rams 323-319-5 (+4 more wins, 647 games played, L1) against the NFC all-time in the regular season

Rams 146-173-3 (-27 more wins, 322 games played, W3) against the NFC AWAY all-time in the regular season

Rams 57-67 (-10 more wins, 124 games played, L1) against the NFC East all-time in the regular season

Rams 29-31 (-2 more wins, 60 games played, W1) against the NFC East AWAY all-time in the regular season

The Rams have a winning percentage at or above .500 for FOUR of the above ten data points. The Rams are currently on a winning streak for EIGHT of the 10 data points listed above.

Eagles are 3-4 (-1 more wins, 7 games played, W2) on September 21st all-time

Eagles 551-564-26 (-13 more wins, 1,141 games played, W3) on Sundays all-time

Eagles 309-246-13 (+64 more wins, 568 games played, W6) on Sundays at HOME all-time

Eagles 97-107-4 (-10 more wins, 208 games played, W1) on Sundays in September all-time

Eagles 53-56-3 (-3 more wins, 112 games played, L1 and L3 for all non-tie games) in September on Sundays at HOME all-time

Eagles 63-70-3 (-7 more wins, 136 games played, W1) in September HOME all-time

Eagles 336-310-6 (+26 more wins, 652 games played, W3) against the NFC all-time in the regular season

Eagles 180-145-3 (+35 more wins, 328 games played, W5) against the NFC all-time HOME in the regular season

Eagles 55-53-1 (+2 more wins, 109 games played, W1) against the NFC West all-time in the regular season

Eagles 26-29-1 (-3 more wins, 56 games played, L6) against the NFC West at HOME all-time in the regular season

The Eagles have a winning percentage at or above .500 for FOUR of the above ten data points. The Eagles are currently on a winning streak for EIGHT of the 10 data points listed above.

Cincinnati Bengals at Minnesota Vikings (CBS)

Pittsburgh Steelers at New England Patriots (CBS)

Los Angeles Rams at Philadelphia Eagles (FOX)

New York Jets at Tampa Bay Buccaneers (FOX)

Las Vegas Raiders at Washington Commanders (FOX)

Atlanta Falcons at Carolina Panthers (FOX)

Houston Texans at Jacksonville Jaguars (CBS)

Predictions to win: Cleveland Browns, Tennessee Titans, Cincinnati Bengals, Pittsburgh Steelers, Philadelphia Eagles, Tampa Bay Buccaneers, Las Vegas Raiders, Carolina Panthers, Jacksonville Jaguars

New York Jets at Tampa Bay Buccaneers (FOX)

Las Vegas Raiders at Washington Commanders (FOX)

Atlanta Falcons at Carolina Panthers (FOX)

Houston Texans at Jacksonville Jaguars (CBS)

Predictions to win: Cleveland Browns, Tennessee Titans, Cincinnati Bengals, Pittsburgh Steelers, Philadelphia Eagles, Tampa Bay Buccaneers, Las Vegas Raiders, Carolina Panthers, Jacksonville Jaguars

Predictions to lose: Green Bay Packers, Indianapolis Colts, Minnesota Vikings, New England Patriots, Los Angeles Rams, New York Jets, Washington Commanders, Atlanta Falcons, Houston Texans

Results: Win, Loss, Loss, Win, Win, Win, Loss, Win, Win

CHANGE IN PREDICTION (Re-predicted on Friday, September 19th, 2025, at 3:19 p.m. Eastern Time)

Predictions to win: Indianapolis Colts

Predictions to lose: Tennessee Titans

Results: Win (1-0)

CHANGE IN PREDICTIONS (Re-predicted at or shortly after game time started on Sunday, September 21st, 2025 on Gab.com/Evan_Troxel)

Predictions to win: Atlanta Falcons

Predictions to lose: Carolina Panthers

Results: Loss

FINAL PREDICTION won-lost results for the early slate of games on Sunday: 6 wins and 3 losses

Sunday, September 21st, 2025 (Late afternoon games)

Denver Broncos at Los Angeles Chargers (4:05 p.m. Eastern Time, CBS)

New Orleans Saints at Seattle Seahawks (4:05 p.m. Eastern Time, CBS)

Dallas Cowboys at Chicago Bears (4:25 p.m. Eastern Time, FOX)

Arizona Cardinals at San Francisco 49ers (4:25 p.m. Eastern Time, FOX)

Predictions to win: Los Angeles Chargers, Seattle Seahawks, Chicago Bears, Arizona Cardinals

Predictions to lose: Denver Broncos, New Orleans Saints, Dallas Cowboys, San Francisco 49ers

Results: Win, Win, Win, Loss (3-1)

CHANGE IN PREDICTION (Re-predicted on Saturday, September 20th, 2025, at 2:44 p.m. Eastern Time)

Prediction to win: San Francisco 49ers

Prediction to lose: Arizona Cardinals

Results: Win (1-0)

Sunday Night Football on Sunday, September 21st, 2025 (NBC, 8:20 p.m. Eastern Time)

Kansas City Chiefs at New York Giants

Predictions to win: Kansas City Chiefs

Predictions to lose: New York Giants

Results: Win (1-0)

FINAL PREDICTIONS won-lost results for all Week 3 games before Monday Night Football: 11 wins and 4 losses

Monday Night Football on Monday, September 22nd, 2025

Detroit Lions at Baltimore Ravens (8:15 p.m. Eastern Time, ABC & ESPN)

Predictions to win: Baltimore Ravens

Predictions to lose: Detroit Lions

Results:

Those are all of my predictions for right now! Be sure to come back to this page for my re-predictions of my NFL original predictions for Regular Season Week 3 (and also to see how many wins and losses I actually get with my original predictions and my re-predictions for Regular Season Week 3) and be sure to come back to this website for my predictions to win and lose for next week (and for every single week after that for the entire 2025-26 National Football League season or until as long as I want to keep making predictions)!

Be sure to follow me on my various social media which you can find on this page for right now. Also, be sure to follow me on Twitter/X @Evan_Troxel. Also, be sure to definitely follow me on Gab @Evan_Troxel as well in case I ever get censored and banned from X and Facebook!

I reserve the right to change my predictions before game time. I also can change my predictions AFTER game time ONLY if I decide BEFORE game time that I want to change my predictions and I just do not have access to the Internet before game time.

LEGAL NOTICE: I DO NOT endorse and I do not encourage people to gamble or bet your own money and other people's money at all! These predictions are not meant to be taken as extremely serious advice for betting and gambling purposes anytime at all in the near future!