NFL 2025-26 Week 4 Regular Season Predictions

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By: Evan Troxel

These are my predictions to win and lose for the 2025-26 National Football League season for Regular Season Week 4 from Thursday, September 25th, 2025, through Monday, September 29th, 2025!

NFL 2025-26 Regular Season Week 4 Predictions (Predicted on Tuesday, August 26th, 2025, at 8:22 p.m. Eastern Time)

Thursday, September 25th, 2025 (Prime Video, 8:15 p.m. Eastern Time)

Seattle Seahawks at Arizona Cardinals

Predictions to win: Arizona Cardinals

Predictions to lose: Seattle Seahawks

Results:

Sunday, September 28th, 2025 (9:30 a.m. Eastern Time, NFL Network & NFL+, Croke Park, Dublin, Ireland)

Minnesota Vikings at Pittsburgh Steelers

Predictions to win: Minnesota Vikings

Predictions to lose: Pittsburgh Steelers

Results:

Sunday, September 28th, 2025 (1:00 p.m. Eastern Time games)

Washington Commanders at Atlanta Falcons (CBS)

New Orleans Saints at Buffalo Bills (CBS)

Cleveland Browns at Detroit Lions (FOX)

Carolina Panthers at New England Patriots (FOX)

Los Angeles Chargers at New York Giants (CBS)

Philadelphia Eagles at Tampa Bay Buccaneers (FOX)

Tennessee Titans at Houston Texans (CBS)

Predictions to win: Washington Commanders, Buffalo Bills, Cleveland Browns, New England Patriots, New York Giants, Tampa Bay Buccaneers, Houston Texans

Predictions to lose: Atlanta Falcons, New Orleans Saints, Detroit Lions, Carolina Panthers, Los Angeles Chargers, Philadelphia Eagles, Tennessee Titans

Results:

Sunday, September 28th, 2025 (Late afternoon games)

Indianapolis Colts at Los Angeles Rams (4:05 p.m. Eastern Time, FOX)

Jacksonville Jaguars at San Francisco 49ers (4:05 p.m. Eastern Time, FOX)

Baltimore Ravens at Kansas City Chiefs (4:25 p.m. Eastern Time, CBS)

Chicago Bears at Las Vegas Raiders (4:25 p.m. Eastern Time, CBS)

Predictions to win: Los Angeles Rams, San Francisco 49ers, Baltimore Ravens, Las Vegas Raiders

Predictions to lose: Indianapolis Colts, Jacksonville Jaguars, Kansas City Chiefs, Chicago Bears

Results:

Sunday Night Football on Sunday, September 28th, 2025 (NBC, 8:20 p.m. Eastern Time)

Green Bay Packers at Dallas Cowboys

Predictions to win: Dallas Cowboys

Predictions to lose: Green Bay Packers

Results:

Monday Night Football on Monday, September 29th, 2025

New York Jets at Miami Dolphins (7:15 p.m. Eastern Time, ESPN)

Cincinnati Bengals at Denver Broncos (8:15 p.m. Eastern Time, ABC)

Predictions to win: Miami Dolphins, Denver Broncos

Predictions to lose: New York Jets, Cincinnati Bengals

Results:

Those are all of my predictions for right now! Be sure to come back to this page for my re-predictions of my NFL original predictions for Regular Season Week 4 (and also to see how many wins and losses I actually get with my original predictions and my re-predictions for Regular Season Week 4) and be sure to come back to this website for my predictions to win and lose for next week (and for every single week after that for the entire 2025-26 National Football League season or until as long as I want to keep making predictions)!

Be sure to follow me on my various social media which you can find on this page for right now. Also, be sure to follow me on Twitter/X @Evan_Troxel. Also, be sure to definitely follow me on Gab @Evan_Troxel as well in case I ever get censored and banned from X and Facebook!

I reserve the right to change my predictions before game time. I also can change my predictions AFTER game time ONLY if I decide BEFORE game time that I want to change my predictions and I just do not have access to the Internet before game time.

LEGAL NOTICE: I DO NOT endorse and I do not encourage people to gamble or bet your own money and other people's money at all! These predictions are not meant to be taken as extremely serious advice for betting and gambling purposes anytime at all in the near future!